Incidence of cognitive impairment post first stroke: a systematic review and meta-analysis

作者：Xinyu Zhang, Hongxia Li, Yuan Li, Xiangwen Hao, Ailipinai Yasen, Xiao-Feng Zheng, Yuxin Bai, Jingqi Chen, Qiuhong Man · 发表于：Frontiers in Neurology · 年份：2026 · DOI：10.3389/fneur.2026.1782749 · 研究领域：Acute Ischemic Stroke Management、Stroke Rehabilitation and Recovery、Dementia and Cognitive Impairment Research

Objective: To clarify the incidence of post-stroke cognitive impairment (PSCI) in first-time stroke patients through meta-analysis. Methods: We conducted a comprehensive search of PubMed, Embase, Web of Science, and the Cochrane Library for studies reporting PSCI incidence up to May 5, 2024. Pooled incidence was calculated using Stata 18.0 with a random-effects model. Results: = 98.63%]. Subgroup analysis showed that the prevalence of PSCI was 38% in male and 45% in female; The prevalence of PSCI was 54% for hemorrhagic stroke and 44% for ischemic stroke; The prevalence of PSCI was 38% in stroke patients possessing hypertension and 32% in stroke patients without hypertension; The prevalence of PSCI was 44% in stroke patients with diabetes and 36% in stroke patients without diabetes; The prevalence of PSCI was 46% in stroke patients with hyperlipidemia and 40% in stroke patients without hyperlipidemia; The incidence of PSCI in stroke patients aged > 60 years was 44%. Conclusion: Nearly half of patients with first-time stroke develop PSCI and the rate is higher in females, patients aged > 60 years, hemorrhagic stroke subtype, and those with hypertension, diabetes, and hyperlipidemia compared to males, ischemic stroke subtype, and those without underlying diseases. Systematic review registration: The protocol for this review was registered with the PROSPERO International Prospective Register of Systematic Reviews (CRD42024611457).