Old Reagent for a Trick in the Stereoselective Hydromethylation of Alkynes Enabled by Cu(I) Photosensitizer Catalysis

作者：Ziwen Huang, Kun Zhang, Xi Chen, Yun-Fang Yang, Yin Xu, Yunkui Liu · 发表于：Organic Letters · 年份：2026 · DOI：10.1021/acs.orglett.6c01090 · 被引用次数：1 · 研究领域：Radical Photochemical Reactions、Catalytic C–H Functionalization Methods、Organoboron and organosilicon chemistry

Herein, an unprecedented exploitation of α-silyl amine as a methyl radical equivalent for the reaction with alkynes has been realized, providing practical access to trisubstituted alkenes with exclusive regioselectivity and generally high E / Z diastereoselectivity. This photoredox protocol features Cu(I) photosensitizer catalysis, mild reaction conditions, and sequential C–Si and C–N bond cleavage. Notably, this transformation unveils a novel reactivity mode of an old reagent and represents a rare example of catalytic alkyne hydromethylation.