Inhibiting MDM2 enhances RIPK3-mediated necroptosis and synergizes with immune checkpoint blockade therapy

作者：Yingxin Wu, Hanyang Yu, Zongxu Zhang, Weihang Xiong, Zexian Zeng, Weili Liu, Hailin Tu, Xin Lin · 发表于：iScience · 年份：2026 · DOI：10.1016/j.isci.2026.115724 · 被引用次数：1 · 研究领域：Cell death mechanisms and regulation、Phagocytosis and Immune Regulation、Cancer-related Molecular Pathways

T cell infiltration, leading to improved tumor control. In immunologically "cold" tumor models, combining MDM2 inhibition with anti-PD-1 blockade converted tumors to a T cell-inflamed state and significantly improved therapeutic efficacy, even in p53-deficient settings. These findings identify MDM2 as a regulator of TNF-α-induced necroptosis and highlight its potential as a therapeutic target for cancer immunotherapy.