Associations of Accelerated Biological Aging With the Presence and Longitudinal Progression of Cerebral Small Vessel Disease

作者：Mengxing Wang, Xueli Cai, Peiyuan Gao, Yingying Yang, Yueru Ding, Ziyan Zhang, Jingping Sun, Yanli Zhang, Dandan Liu, Yongjun Wang, Yilong Wang, Yuesong Pan · 发表于：Neurology · 年份：2026 · DOI：10.1212/wnl.0000000000214818 · 被引用次数：2 · 研究领域：Cerebrovascular and genetic disorders、Genetics, Aging, and Longevity in Model Organisms、Mitochondrial Function and Pathology

BACKGROUND AND OBJECTIVES: Cerebral small vessel disease (CSVD) is a major cause of dementia and stroke, typically identified by lesions such as white matter hyperintensity (WMH), lacunes, cerebral microbleeds (CMBs), enlarged perivascular spaces, and brain atrophy. Biomarker-based biological age (BA), derived from routinely measured clinical indicators and largely reflecting vascular and metabolic physiologic burden, may provide complementary information beyond chronological age. The aim of this study was to investigate the associations between BA residual and both the presence and progression of CSVD and its neuroimaging manifestations. METHODS: In the population-based Polyvascular Evaluation for Cognitive Impairment and Vascular Events cohort, participants underwent brain magnetic resonance imaging (MRI) at baseline (2017-2019) and at follow-up (2022-2024). BA was estimated using 3 established methods: PhenoAge, Klemera-Doubal method, and homeostatic dysregulation. Progression of CSVD and its imaging markers, including new lacunes, new CMBs, progression of enlarged perivascular spaces in the basal ganglia (BG-EPVS), and progression of WMHs, was assessed. Associations between BA residual and progression of CSVD were analyzed using logistic or ordinal logistic regression models, as appropriate. RESULTS: = 0.028), but not with progression of BG-EPVS or WMHs at follow-up. PhenoAge residual showed results consistent with those of KDMAge residual, whereas HDAge residual showed n...