Assessing the global burden of acute viral hepatitis in the elderly: a comprehensive analysis of data from the GBD 2021 database

作者：Tongjing Xing, Hongwei Wu, A. Li, Hui Shao, He Qu, Jiapei Ding, Xuequan Wang · 发表于：BMC Infectious Diseases · 年份：2026 · DOI：10.1186/s12879-026-13112-0 · 研究领域：Hepatitis C virus research、Hepatitis Viruses Studies and Epidemiology、Hepatitis B Virus Studies

OBJECTIVE: Despite advances in prevention and treatment, the burden of acute viral hepatitis (AVH) remains substantial yet understudied in the elderly. In this study, we used data from the Global Burden of Disease (GBD) 2021 database to analyze burden, inequality, and trends associated with acute hepatitis from 1990 to 2021 in individuals aged 60 years and above. METHODS: Data on AVH burden in the elderly were extracted from the GBD 2021 database for analysis of age-standardized prevalence rates (ASPR), age-standardized incidence rates(ASIR), age-standardized mortality rates(ASMR), age-standardized disability-adjusted life years [DALYs] rates(ASDR) and demographic factors (gender, age group). Analytical techniques included joinpoint regression, decomposition analyses, and predictive modeling to assess temporal trends and future projections. RESULTS: From 1990 to 2021, trends in global age-specific prevalence, incidence, mortality, and DALY rates (ASPR, ASIR, ASMR, and ASDR, respectively) were consistently downward. Specifically, low–Social Development Index (SDI) countries exhibited higher prevalence, incidence, and mortality rates and more DALYs. Frontier analysis showed that the AVH-related ASDR from 1990 to 2021 generally decreased with increasing SDI, indicating that higher levels of social development were associated with better health outcomes in the elderly. Generally, age analysis indicated declines in prevalence and incidence with age, with a valley around 85–89 year...