Progress and challenges of mesenchymal stem cells as oncolytic virus delivery systems: A bibliometric analysis of the top 100 most-cited papers in the past ten years

作者：Jing Jing Liu, Xiao Qi, Soo Young Hur, Paul Pollmächer, Zhimin He, Fang Li · 发表于：Cancer Plus · 年份：2026 · DOI：10.36922/cp026040004 · 研究领域：Virus-based gene therapy research、Mesenchymal stem cell research、3D Printing in Biomedical Research

Oncolytic virotherapy has emerged as a promising approach to cancer treatment, and mesenchymal stem cells (MSCs) are increasingly recognized as effective carriers to enhance the delivery and efficacy of oncolytic viruses (OVs). This study explores the potential use of MSCs as carriers for OVs in targeted cancer therapy. MSCs are considered ideal delivery vehicles for OVs due to their immunomodulatory properties, inherent tumor-homing ability, and capacity to protect and transport therapeutic agents. Advances in genetic engineering have enhanced the interaction between MSCs and OVs, improving delivery efficiency and therapeutic outcomes in cancer treatment. This study conducted a bibliometric analysis of the 100 most-cited articles on both MSCs and OVs, using data from the Web of Science Core Collection database. It identified major trends, challenges, and research hotspots, highlighting significant progress in preclinical studies while noting ongoing issues related to delivery efficiency, virus modification, and tumor microenvironment optimization. The findings underscore the promise of MSCs as effective delivery systems for Ovs and outline emerging research areas, such as precise delivery methods and clinical applications, alongside current obstacles. As this field advances, it is expected to play a crucial role in the future of cancer immunotherapy.