Hmgcs1 regulates cholesterol synthesis and promotes nerve fiber repair after spinal cord injury

作者：Yingfan Pei, Guoying Feng, Yaorui Hu, Jiaran Tang, Naili Zhang, Shuai Zhou, Chunlei Zhang, Fei Huang, Luping Zhang · 发表于：iScience · 年份：2026 · DOI：10.1016/j.isci.2026.115692 · 研究领域：Nerve injury and regeneration、Spinal Cord Injury Research、Inflammasome and immune disorders

co-culture system. Finally, RNA sequencing (RNA-seq) and quantitative reverse-transcription PCR (qRT-PCR) were integrated to elucidate Hmgcs1-mediated signaling pathways by validating downstream target gene expression. The results demonstrated that Hmgcs1 overexpression enhanced cholesterol synthesis in astrocytes post-injury, effectively promoted neuronal myelin repair, axonal regeneration, and improved motor functional recovery in rats. Notably, neuropilin-1 (Nrp1) expression exhibited Hmgcs1-dependent regulation.