Joint associations of grip strength, lipid levels, and lipid-related genetic risk with atrial fibrillation

作者：Zihao Zhang, Jianfeng Huang, Xu Wang, Qing Li, Yirong Yang, Kuan Ning, Yifan Wang, Tanxiu Chen, Rui Xiong, Xinjie Liu, Shaolie Huang, Lijuan Deng, Pingping Shen, Yian Zhan, S. Xiao, Wen‐Quan Zou · 发表于：Lipids in Health and Disease · 年份：2026 · DOI：10.1186/s12944-026-02941-2 · 被引用次数：1 · 研究领域：Atrial Fibrillation Management and Outcomes、Cardiovascular Disease and Adiposity、Folate and B Vitamins Research

INTRODUCTION: The associations between lipid levels and atrial fibrillation (AF) remain inconsistent, and whether functional status modifies these relationships is unclear. In this prospective cohort study, the joint associations of grip strength, lipid levels, and lipid-related genetic risk with incident AF were evaluated. METHODS: A prospective cohort analysis was conducted, and Cox models were used to evaluate the associations of lipid levels, lipid-related polygenic risk scores (PRSs), and grip strength with incident AF. Joint exposure categories were constructed according to lipid status (normal vs. elevated) and grip strength level (normal vs. reduced) to compare AF risk across different combinations. Age-stratified analyses were further conducted to examine age-related heterogeneity. Interaction terms between lipid levels and grip strength were included to test interaction and assess the effect modification of grip strength on the lipid-AF association. Participants receiving lipid-lowering therapy at baseline were excluded in sensitivity analyses. RESULTS: Lipid levels, lipid-related PRSs, and grip strength were each associated with incident AF. In joint exposure analyses, individuals with both elevated lipid levels and reduced grip strength had a lower risk of AF than those with elevated lipids but normal grip strength in the overall population [HR 0.925 (0.889, 0.961)]. However, among participants younger than 55 years, the coexistence of elevated lipids and reduced ...