Neurological and neurodevelopmental outcomes in neonates and children after maternal chikungunya infection in pregnancy: a systematic review and meta-analysis

作者：Liyan Zhou, Chenyuan Qin, Jie Deng, Yan Xing, Hongguang Chen, Daniel R. Lucey, Jue Liu · 发表于：EClinicalMedicine · 年份：2026 · DOI：10.1016/j.eclinm.2026.103888 · 被引用次数：1 · 研究领域：Mosquito-borne diseases and control、Viral Infections and Immunology Research、Malaria Research and Control

Background Chikungunya virus (CHIKV) is a re-emerging Aedes-borne virus with documented vertical transmission in pregnancy. Neurological and neurodevelopmental outcomes in neonates and children have important clinical and societal implications, yet evidence remains limited and fragmented. We therefore undertook a quantitative meta-analysis and narrative synthesis on neurological and neurodevelopmental outcomes in neonates and children after maternal chikungunya infection in pregnancy. Methods In this systematic review and meta-analysis, we searched PubMed, Embase, Web of Science, and Scopus from inception to January 3, 2026, with no language restrictions. We included observational studies reporting neurological outcomes in neonates and/or children after maternal CHIKV infection during pregnancy. Prespecified exclusion criteria were duplicate records/publications; non-original reports; non-human studies; and reports without useable outcome data for synthesis. Quantitative outcomes were: (1) the pooled proportion of acute neonatal neurological outcomes among neonates with confirmed vertical CHIKV infection (≤28 days), and (2) the relative risk (RR) of adverse neurodevelopmental outcomes (>28 days) in children born to mothers with CHIKV infection compared with children of uninfected mothers. Quantitative outcomes were pooled using random-effects meta-analysis (Freeman–Tukey for proportions; inverse-variance pooling for RRs), with heterogeneity assessed by I 2 . Risk of bias was ...