MyGeneRisk Colon: A Web-Based Tool for Personalized Colorectal Cancer Risk Prediction Based on Genetics and Lifestyle

作者：Jiayin Zheng, Robert S. Steinfelder, Hang Yin, Conghui Qu, Minta Thomas, Sushma Thomas, Cynthia Andrews, Bianca Augusto, Douglas Corley, Jeffrey K Lee, Sonja I Berndt, Andrew T. Chan, SJ Chanock, Chris Gignoux, S. Goldberg, Christopher A Haiman, Jeroen R Huyghe, Motoki Iwasaki, L. Le Marchand, S. C. Lee, Johana Meléndez, Ivan Mesa, Shuji Ogino, Viviam Sifontes, Caroline Y Um, Kala Visvanathan, Larissa L. White, Andrea Williams, Waverly Willis, Alicja Wolk, Taiki Yamaji, Susan T Vadaparampil, Gail P. Jarvik, A. N. Burnett-Hartman, Roger L Milne, Elizabeth A Platz, Jane C. Figueiredo, Wei Zheng, Robert J MacInnis, Julie R Palmer, Stephanie L Schmit, Iris Landorp-Vogelaar, Ulrike Peters, Li Hsu · 发表于：medRxiv · 年份：2026 · DOI：10.64898/2026.04.03.26349669 · 研究领域：Colorectal Cancer Screening and Detection、Genetic Associations and Epidemiology、BRCA gene mutations in cancer

Abstract Colorectal cancer (CRC) is a leading cause of cancer-related death, with incidence rising substantially among individuals under 50 years of age. Polygenic risk scores (PRS) hold promise for identifying high-risk individuals; when combined with lifestyle factors, they substantially improve prediction accuracy compared with models based on lifestyle factors alone. However, few clinical tools currently exist that facilitate this integrated, PRS-enhanced risk assessment. To bridge this gap, we developed MyGeneRisk Colo n, a publicly accessible web portal that delivers individualized CRC risk prediction by incorporating genetic, demographic, family history, and lifestyle factors. This paper details the development of the underlying risk prediction model, the portal’s architecture and data security, our reporting framework, and engagement with a community advisory panel. Designed as a user-friendly platform, MyGeneRisk Colon aims to effectively communicate personalized CRC risk profiles and educate users and healthcare providers about prevention strategies.