Abstract 7882: Bridging data gaps in pediatric osteosarcoma: The first registry-based analysis of Puerto Rican cases

作者：MiaSara Perez Salvá, Rocío K. Rivera-Valentín, C. Rodriguez, Liliana Marie Castro-Jimenez · 发表于：Cancer Research · 年份：2026 · DOI：10.1158/1538-7445.am2026-7882 · 研究领域：Sarcoma Diagnosis and Treatment、Neuroblastoma Research and Treatments、Bone Tumor Diagnosis and Treatments

Abstract Despite therapeutic advances, pediatric osteosarcoma (OS) outcomes remain shaped by systemic disparities in access to timely diagnosis and specialized care. In Puerto Rico, where pediatric OS services are centralized and off-island referrals are common, these challenges are magnified. No prior study has documented the demographic or clinical characteristics of this population. This retrospective cohort study analyzed 44 patients under 21 years of age diagnosed with OS using data from the Puerto Rico Central Cancer Registry and the UPR Pediatric Hospital (HOPU). Variables included region of residence, insurance type, tumor site, metastasis at diagnosis, percentage of tumor necrosis, amputation status, Li-Fraumeni syndrome, treatment location, and survival. Tumor sites were overwhelmingly involved in long bones (84%), with the lower extremities representing 80% of cases, predominantly in the distal femur and proximal/distal tibia. No vertebral primaries were identified. Upper extremity tumors accounted for 13.6%, while craniofacial involvement (mandible) represented 6.8%. Although 61% of patients had private insurance, 54% underwent surgical treatment in the U.S, indicating that financial coverage does not necessarily compensate for limited local pediatric orthopedic oncology capacity. Among those treated off-island, 31% received care at St. Jude Children’s Research Hospital and 23% at other high-volume U.S centers, reflecting the need for complex limb-salvage infrastr...