Abstract 5075: Integrated clinicopathologic, genomic and transcriptomic characterization of gastric cancer by race/ethnicity in a national multi-institutional cohort

作者：Kyle D. Klingbeil, Sinéad Cullina, Natalie Martinez, Mariah B. Blegen, Kyla Wright, R. Vanessa Mora Molina, Ami Hayashi, Adam Dugan, Unnati Jariwala, Stamatina Fragkogianni, Jonathan Boiarsky, Lee S. Rosen, Mark D. Girgis, Brian E. Kadera · 发表于：Cancer Research · 年份：2026 · DOI：10.1158/1538-7445.am2026-5075 · 研究领域：Cancer Genomics and Diagnostics、Single-cell and spatial transcriptomics、Ferroptosis and cancer prognosis

Abstract Background: Although gastric cancer outcomes vary by race/ethnicity, a molecular basis for these differences has not been fully elucidated. To address this gap, we used the Tempus Lens Platform (Tempus AI, Inc., Chicago, IL) to query the multimodal de-identified database in order to establish and subsequently analyze a cohort of patients with gastric adenocarcinoma who underwent germline and tumor testing using xT (DNA) and xR (RNA). Methods: Patients were categorized by R/E. RNA-seq data were normalized as transcripts per million (TPM) and reported as log2(TPM+1). Single-sample Gene Set Enrichment Analysis (ssGSEA) using Hallmark gene sets was used to compare cell signaling pathway activity. Real-world overall survival (rwOS) was defined as the time from biopsy to death or last known follow-up. rwOS survival curves were estimated using the Kaplan Meier (KM) approach and differences tested using log-rank tests. Hazard ratios (HR) were calculated using Cox proportional hazard models. Results: Among 1,842 patients with reported race/ethnicity data, 1,186 (64%) identified as White, 327 (17.7%) as Hispanic/Latino (HL), 217 (11.8%) as Black or African American (AA) and 112 (6.1%) as Asian. In the multivariable Cox model, compared to White patients, rwOS was longer for HL (HR 0.65, 95% CI 0.48-0.88, p=0.005) and Asian (HR 0.64, 95% CI 0.41-0.98, p=0.042) patients. Asian patients had longer median rwOS compared to White patients (19 vs 10.9 months, log-rank p<0.001)....