Abstract 3945: Serum detection of MUC1 and renin identifies circulating biomarkers for breast cancer prognosis.

作者：Alakesh Bera, H. Hu, CD Shriver, Meera Srivastava · 发表于：Cancer Research · 年份：2026 · DOI：10.1158/1538-7445.am2026-3945 · 研究领域：Ferroptosis and cancer prognosis、Mechanisms of cancer metastasis、Inflammation biomarkers and pathways

Abstract Background: Cytogenetic abnormalities involving multiple loci on the long arm of chromosome 1 are among the most frequent alterations in human breast carcinoma. To define their biological and clinical significance, we conducted a large-scale integrative genomic analysis across diverse breast cancer datasets. Methods: Data from over 13,000 breast tumors (n = 13,146 samples; 12,229 patients across 30 studies) were analyzed using cBioPortal, including The Cancer Genome Atlas (TCGA). Copy number alterations, mRNA/protein expression, and clinical outcomes were evaluated. Comparative analyses with >100,000 samples across 35 other cancers (n = 105,424) determined specificity. Mutual exclusivity and co-occurrence analyses identified genetic interaction patterns relevant to tumor progression. Serum detectability of top candidates was evaluated. Results: Eight genes particularly TRIM67, DISC1, REN, DNM3, ATP1B1, VSIG8, SPTA1, and MUC1 from different loci of 1q chromosome showed recurrent amplifications (12-15%) in breast tumors, significantly exceeding frequencies in pan-cancer datasets (∼3%). These genes displayed low baseline expression in normal breast tissue but were highly expressed in tumors. Co-occurrence analyses revealed significant genetic interplay, including TP53 with MUC1/SPTA1/VSIG8 and PIK3CA with TRIM67/DISC1/REN, suggesting cooperative gain-of-function driving aggressive phenotypes. Among the eight amplified 1q genes, MUC1 and REN showed the strongest c...