Abstract 2350: Subtype-specific patterns of peripheral T-cell lymphoma in diverse Asian populations.

作者：Xuanxi Kuang, Esther Lam, Mallory Bernstein, Nicole Foley, Lauren Pinter-Brown, Megan S. Lim, Wendy Cozen · 发表于：Cancer Research · 年份：2026 · DOI：10.1158/1538-7445.am2026-2350 · 研究领域：Lymphoma Diagnosis and Treatment、T-cell and Retrovirus Studies、CNS Lymphoma Diagnosis and Treatment

Abstract Peripheral T-cell lymphomas (PTCLs) are rare, aggressive non-Hodgkin T-cell lymphomas with a poor prognosis. Black individuals have a higher incidence compared to White individuals, but little is known about incidence rates for specific Asian populations. We obtained average annual age-adjusted incidence rates (AAIR)/100,000 based on the age distribution for the US 2000 Census for PTCL-not otherwise specified (ICD-O-3: 9702), angioimmunoblastic T-cell lymphoma (AITL, 9705), and anaplastic large cell lymphoma (ALCL, 9714) within Asian subpopulations, in addition to rate ratios(RR) comparing racial/ethnic groups with non-Hispanic whites (NHW) as a reference group. Data was obtained from the Surveillance, Epidemiology, and End Results (SEER) 9 registry (1990-2014). The combined-subtype analysis showed no significant difference between Asian-Pacific Islanders overall and NHW (RR 0.94; p=0.0976), but stratified analysis in SEER showed striking differences. Southeast Asians had the highest incidence rates, followed by Filipinos, while Chinese had the lowest incidence rates (Table 1). By subtype, Southeast Asians had the highest incidence rates of PTCL-NOS (0.72/100,000, RR= 2.40, p=0.002, based on 21 cases), followed by Filipinos (0.45/100,000, RR=1.49, p<0.001). Both Filipinos (p=0.0004) and Vietnamese (p=0.05) had higher incidence rates of AITL (0.18/100,000) compared to NHW (0.1/100,000) with RR=1.73. NHW had the highest incidence rates of ALCL (0.23/100,000). Co...