Modest and Variable Correlations Between Geographic Atrophy Enlargement Rates in Fellow Eyes in the AREDS2 Study

作者：L. von der Emde, Emily Vance, Souvick Mukherjee, Jintong Hou, Elvira Agrón, Fares Siddiq, Amitha Domalpally, Usha Chakravarthy, Emily Y. Chew, Tiarnán D L Keenan · 发表于：JAMA Ophthalmology · 年份：2026 · DOI：10.1001/jamaophthalmol.2026.0540 · 被引用次数：3 · 研究领域：Visual perception and processing mechanisms、Ophthalmology and Eye Disorders、Face Recognition and Perception

Importance: In bilateral geographic atrophy (GA), enlargement rates in fellow eyes are often assumed to be highly correlated. On this basis, researchers have inferred treatment effects and proposed GA trials using the untreated fellow eye as an internal control. Objective: To quantify the correlation in GA enlargement rates between fellow eyes. Design, Setting, and Participants: This was a post hoc analysis of Age-Related Eye Disease Study 2 (AREDS2), a multicenter study of patients in retinal specialty clinics throughout the US. Included in the analysis were participants of the AREDS2 trial with bilateral GA. Study data were analyzed from May 2025 to January 2026. Exposures: GA in the fellow eye. Main Outcomes and Measures: Pearson correlation coefficient for 2-year GA enlargement rates in eye pairs. Rates were derived from planimetry of annual fundus photographs and expressed as untransformed, square root-transformed, and perimeter-adjusted rates. Correlation was analyzed overall and within clinically relevant strata. Results: A total of 386 eyes of 193 AREDS2 participants (mean [SD] age, 75.5 [7.3] years; 118 female [61.1%]) with bilateral GA were included in this analysis. Correlations in enlargement rates varied substantially by transformation used as follows: moderate for untransformed (r = 0.51; 95% CI, 0.41-0.61), weak to moderate for square root-transformed (r = 0.38; 95% CI, 0.25-0.49), and very weak for perimeter-adjusted (r = 0.11; 95% CI, -0.03 to 0.25) rates. Co...