Frailty Transition Among Older Adults Living With HIV in Thailand: A 5‐Year Longitudinal Study

作者：Tanakorn Apornpong, W. Min Han, Akarin Hiransuthikul, Hay Mar Su Lwin, Napon Hiranburana, Sasiwimol Ubolyam, Stephen J. Kerr, Thira Woratanarat, Anchalee Avihingsanon, HIV‐NAT 006 and 207 study team · 发表于：Journal of the International AIDS Society · 年份：2026 · DOI：10.1002/jia2.70099 · 被引用次数：1 · 研究领域：Frailty in Older Adults、HIV-related health complications and treatments、HIV/AIDS Research and Interventions

ABSTRACT Introduction Frailty is highly prevalent among older people with HIV (PWH), driven by multimorbidity and HIV‐associated accelerated ageing. We investigated frailty transitions and associated factors over a 5‐year follow‐up period in an ageing cohort of PWH in Thailand. Methods We conducted a prospective cohort study among PWH aged ≥50 years in Bangkok, Thailand, between May 2015 and June 2024. Frailty phenotypes were assessed at baseline and at 5 years of follow‐up using the Fried frailty phenotype, including unintentional weight loss, low physical activity, exhaustion, weak grip strength and slow walking speed. Multinomial logistic regression was performed to identify factors associated with frailty progression and reversibility over follow‐up. Results Among 324 participants enrolled (63% male; median age of 54 [IQR, 52−59] years), 158 (49%) were robust, 153 (47%) were pre‐frailty and 13 (4%) were frailty at baseline. Over 5 years, 111 participants (34%) experienced frailty worsening, 158 (49%) remained stable and 55 (17%) demonstrated frailty reversal. Among 158 PWH who were robust at baseline, 75 (47%) remained robust, 57 (36%) transitioned to pre‐frailty and 26 (16%) progressed to frailty. Notably, among those frail at baseline ( N = 13), 65% improved to pre‐frailty or robustness. Low physical activity was the most common frailty component at baseline, while weak grip strength was the most predominant frailty phenotype at year 5. In multivariable analysis, multim...