Relationship Between Clostridioides difficile Stool Concentration, Nucleic Acid Amplification Test Results, and Environmental Contamination

作者：Mary Morgan Lee, Kimberly A. Reske, Tiffany Hink, Skye R. S. Fishbein, Erin Newcomer, Candice Cass, Margaret A. Olsen, Gautam Dantas, Carey‐Ann D. Burnham, Erik R. Dubberke · 发表于：Open Forum Infectious Diseases · 年份：2026 · DOI：10.1093/ofid/ofag121 · 被引用次数：2 · 研究领域：Clostridium difficile and Clostridium perfringens research、Infection Control in Healthcare、Antibiotic Use and Resistance

Abstract We compared rectal swab nucleic acid amplification testing (NAAT) with stool culture to detect Clostridioides difficile colonization and correlated results with environmental contamination. Rectal swab NAAT sensitivity (43%) for detecting toxigenic C. difficile colonization was low. Toxigenic culture-positive patients were more likely to have C. difficile detected in the hospital environment.