Schiff Base-Wrapped Co, Zn-Based Clusters with Hierarchical Chiral Structures for Therapeutic Application in Parkinson’s Disease

作者：Ling-Cui Meng, Jie Chen, Lu-Yao Xu, Jun Wang, Zhan‐Guo Jiang, Zhigang Jin, Cai‐Hong Zhan · 发表于：Inorganic Chemistry · 年份：2026 · DOI：10.1021/acs.inorgchem.6c00360 · 被引用次数：33 · 研究领域：Synthesis and Properties of Aromatic Compounds、Catalytic Cross-Coupling Reactions、Magnetism in coordination complexes

Hierarchical chiral structures have wide applications in materials science and biomedicine. The synthesis of multilevel chiral structures with specific functions is a key issue. In this work, we have successfully designed and synthesized R/S-Co 4 Zn 5 L 10 (L = C 16 H 15 O 3 N) quinary chiral helix, in which the chirality transfers from the chiral carbon atoms of ligands to octahedral stereochirality, then to a single helix, further to a supramolecular helical chain, and ultimately to the chiral crystal structure. R/S-Co 4 Zn 5 L 10 consists of two chiral building units, R/S-Zn 3 L 2 and R/S-CoL 2 . R/S-CoL 2 can also agglomerate into R/S-Co 4 L 6 . The evaluation of the biocompatibility and bioactivity for three pairs of enantiomers reveals that R-Co 4 Zn 5 L 10 and R-CoL 2 effectively restore dopaminergic neuron loss and improve dopamine-dependent locomotion deficits in nematodes. Additionally, these compounds inhibit α-synuclein aggregation during nematode development. These findings suggest that elaborately designed cobalt-based chiral structures have potential as novel therapeutic candidates for Parkinson’s disease.