Associations of eight insulin resistance-related indices and genetic risk with incident cardiometabolic multimorbidity among participants with hypertension: a large prospective cohort study

作者：Shaowei Ma, Min Jiang, Ying Xuan, Yucheng Shen, Kuanbing Chen, Bo Li · 发表于：Cardiovascular Diabetology · 年份：2026 · DOI：10.1186/s12933-026-03154-8 · 被引用次数：4 · 研究领域：Diabetes, Cardiovascular Risks, and Lipoproteins、Chronic Disease Management Strategies、Cardiovascular Function and Risk Factors

BACKGROUND: Cardiometabolic multimorbidity (CMM) is prevalent among individuals with hypertension. Although insulin resistance (IR)-related indices have been linked to CMM, their associations with incident CMM in hypertensive populations remain unclear. This study examined the associations in this high-risk group, focusing on the roles of genetic factors and biomarkers. METHODS: This observational prospective cohort analysis used data from the UK Biobank, comprising 129,853 hypertensive patients free of pre-existing coronary heart disease, stroke, or type 2 diabetes. Eight IR-related indices were computed: triglyceride-glucose (TyG) index, TyG-body mass index (TyG-BMI), TyG-waist circumference (TyG-WC), TyG-waist-to-height ratio (TyG-WHtR), TyG-a body shape index (TyG-ABSI), TyG-weight-adjusted waist index (TyG-WWI), TyG-body roundness index (TyG-BRI), and triglyceride to high-density lipoprotein cholesterol ratio (TG-HDL-C). Associations were examined using Cox proportional hazards models. Incremental predictive value was quantified using the net reclassification improvement, integrated discrimination improvement, and the C index. We also analyzed their joint and interaction effects with genetic risk and conducted exploratory biomarker analyses. RESULTS: Over a median follow-up of 13 years, 28,455 incident CMM events were recorded. Multivariable-adjusted hazard ratios (95% CIs) the highest versus lowest tertiles were: 1.78 (1.73-1.83) for TyG index, 2.10 (2.04-2.17) for TyG-...