Visible-Light-Mediated Multicomponent Synthesis of Azido-Substituted gem -Difluoroalkenes

作者：Jiabin Shen, Du Hu, Ye Chen, Hao Xu, Donghao Wang, Kai Ge, Chao Shen, Min Wang · 发表于：The Journal of Organic Chemistry · 年份：2026 · DOI：10.1021/acs.joc.6c00207 · 被引用次数：8 · 研究领域：Fluorine in Organic Chemistry、Click Chemistry and Applications、Radical Photochemical Reactions

Herein, a photocatalytic strategy for the synthesis of gem -difluoroalkenes by the multicomponent cascade reaction of α-trifluoromethyl alkenes with alkenes and TMSN 3 is described. This operationally simple protocol provides a powerful strategy to introduce azido fragments into gem -difluoroalkenes, enriching the current library of gem -difluoroalkenes for drug discovery. A gram-scale synthesis and synthetic applications demonstrate the potential application of this methodology in the synthesis of diverse medicinally relevant compounds.