Volume vs intensity of physical activity and risk of cardiovascular and non-cardiovascular chronic diseases

作者：Jiehua Wei, Minxue Shen, Shenxin Li, Yi Xiao, D. Luo, Gerson Ferrari, Dong Hoon Lee, Leandro F. M. Rezende, Jason M. R. Gill, Matthew N Ahmadi, Emmanuel Stamatakis, Xiang Chen · 发表于：European Heart Journal · 年份：2026 · DOI：10.1093/eurheartj/ehag168 · 被引用次数：7 · 研究领域：Physical Activity and Health、Obesity, Physical Activity, Diet、Mobile Health and mHealth Applications

BACKGROUND AND AIMS: While vigorous physical activity (VPA) is known to provide greater health benefits per unit time than moderate activity, the spectrum of these benefits across different chronic diseases and the relative importance of physical activity (PA) intensity vs volume remain unclear. This study examined associations between the proportion of VPA (%VPA) relative to total volume of PA and the incidence of multiple chronic disease outcomes. METHODS: This prospective population-based cohort study included 96,408 participants (mean age 61.9 years, women: 56.3%) with device-measured data (wrist-worn accelerometers) and 375,730 participants (mean age 56.2 years, women: 52.2%) with self-reported PA data (IPAQ) from the UK Biobank. Main outcomes included incidence of eight chronic diseases: major adverse cardiovascular events (MACE), atrial fibrillation (AFib), type 2 diabetes (T2D), immune-mediated inflammatory diseases, metabolic dysfunction-associated steatotic liver disease (MASLD), chronic respiratory diseases (CRD), chronic kidney disease (CKD), and dementia, as well as all-cause mortality. Cox proportional hazards models were used to estimate adjusted hazard ratios and 95% confidence interval. RESULTS: In the device-measured data, non-linear inverse dose-response relationships were observed between %VPA and all outcomes (all P < .001), and these patterns remained consistent across strata of total PA volume. In multivariable models adjusted for total PA volume, parti...