Intracranial Plaque Characteristics and Extracranial Carotid Plaque‐ RADS Associated With Stroke Recurrence: A High‐Resolution Vessel Wall Imaging Study

作者：Wenqiao Zheng, Yichun Qu, Fanyu Du, Zhichang Fan, Yan Li, Bin Wang, Yongfang Wang, Lu Wang, Xiaochun Wang · 发表于：Journal of Magnetic Resonance Imaging · 年份：2026 · DOI：10.1002/jmri.70313 · 被引用次数：1 · 研究领域：Cerebrovascular and Carotid Artery Diseases、Acute Ischemic Stroke Management、Cardiovascular Health and Disease Prevention

BACKGROUND: In addition to intracranial plaques, extracranial carotid plaques have also been linked to stroke recurrence. However, the association of combined intracranial and extracranial plaque characteristics with stroke recurrence remains unclear. PURPOSE: To evaluate the association between intracranial plaque features and extracranial carotid Plaque Reporting and Data System (Plaque-RADS) with stroke recurrence utilizing high-resolution vessel wall imaging (HR-VWI). STUDY TYPE: Retrospective. POPULATION: The 388 intracranial atherosclerotic ischemic stroke patients (mean age, 57.3 ± 11.5 years, 274 males). FIELD STRENGTH/SEQUENCE: 3T, three-dimensional T1 weighted 3D fast spin echo. ASSESSMENT: HR-VWI was performed in all patients within 7 days of the stroke onset. The imaging features assessed included intracranial plaque characteristics (degree of stenosis, plaque burden, enhancement ratio, remodeling index, and intraplaque hemorrhage [IPH]) and extracranial carotid Plaque-RADS. Patients enrolled between May 2022 and July 2024 were included in the study. All patients were followed for a minimum of 12 months. STATISTICAL TESTS: test, univariate and multivariate Cox regression analyses, time-dependent ROC and AUC curves, and Kaplan-Meier survival curves. p-values less than 0.05 were regarded as statistically significant. RESULTS: During a median follow-up period of 24 months, 55 patients experienced recurrent stroke. Intracranial plaque enhancement ratio (HR, 1.62; 95% ...