Progress towards the WHO Global Initiative for Childhood Cancer target of 60% 5-year survival for all childhood cancers combined, 1990–2019 (CONCORD-4): a Cancer Survival Index derived for 68 countries by analysis of individual records for 613 021 children from 307 population-based cancer registries

作者：Claudia Allemani, V Di Carlo, Naomi Ssenyonga, Fatima Khan Baloch, Claudia E Kuehni, Claudia Kuehni, Fabio Girardi, Carolina Goić, Marisa K Sophiea, Mario Šekerija, Carla Espinoza-Vallejos, Katerina Dadouli, Hiromi Sugiyama, Jaume Galceran, Adela Cañete-Nieto, Rosalia Ragusa, Florencia Moreno, Charles Stiller, Michel P Coleman, S. Bouzbid, Soumaya Amarouche, N. Boussouf, M Hamdi-Chérif, Lamia Kara, A Ladipo, Olufemi Ogunbiyi, Claude Alcaraz, Emmanuel Chirpaz, Nontuthuzelo IM Somdyala, M A Chaplin, Florencia Moreno, Kern Rocke, Natasha P Sobers, Magna S Alexandre-Moreira, Herbert CS Barros, Brenda EB da Silva, Carlos Anselmo Lima, Walmiro Ferreira Ramos Neto, Fabiana Lima Vazquez, Gil PM Pena, Juliana Nativio, Paulo César F De Souza, J. Chaves, C. Laporte, Cristiane Bastos Daniel, Márcia Cristina de Sousa Reis, Karine Meireles do Valle, Jose Carlos Oliveira, Claudia LA Veneziano, D. B Veneziano, Gulnar Azevedo e Silva, Roberto de Almeida Gil, Marise Souto Rebelo, Heather M Armstrong, Sarah Quesnel-Crooks, Gianfranco Cossani, Alvaro L Montiel, María Paz Sandoval, Patricia Cerda, Kelly Gianina Núñez, Carla Espinoza-Vallejos, Karen Rosas, D.A. Herrmann, Solange Melina Gómez Vargas, Christian R Garcia, Carolina Goic, Claudia M Hormiga Sánchez, Claudia Uribe, Armando D Cortés Buelvas, Elvia Karina Grillo Ardila, Nelson Enrique Arias-Ortiz, Alexandra Giraldo-Osorio, Luisa M Bravo Goyes, Harold M Casas Cruz, Sandra Lucía Suárez Delgado, Adriana M. Torres, Leticia M Fernández Garrote, Y H Galán Alvarez, Nicolás Luciano Campoverde Arévalo, Maria Jose Orbe Muñoz, Leyda Elizabeth Jaramillo Feijoo, Jhony Joe Real Cotto, J Castillo, Anny Gomez, Juan González, Wilmer Tarupi, Monica L Carranza Mena, Soad Fuentes-Alabi, Kinan Drak Alsibai, Mathieu Nacher, Bernard Bhakkan, Jacqueline Deloumeaux, Tatiana Lizarazo Balcárcel, Clàudia Garrido, Clarisse Joachim, Jonathan Macni, Rebeca Rivera Gómez, Luis E Medina Fernández, Berenice Rodriguez Zea, Patricia Perez, Ebert Poquioma, Karen J Ortiz-Ortiz, Carlos R Torres-Cintrón, Nkese Felix, Emily Prince-Joseph, Rafael Alonso, Carina Musetti, Angela Eckstrand, Lorraine Shack, Jonathan Simkin, Ryan Woods, Sheila Fukumura, Donna Turner, Eshwar Kumar, Bin Zhang, Jeff Dowden, Gregory P. Doyle, Sarah Jeffrey, Peter Workman, Nathalie Saint-Jacques, Gordon Walsh, Prithwish De, Todd A Norwood, Carol A McClure, Karen AM Phillips, Laci Davis, Serena Kozie, T Freeman, Justin T George, Rosa M. Avila, Julie M. Cleaton, Dana Doyle, Georgia Yee, Lindsay M Collins, Daniela Ramirez Aguilar, Lyn Almon, Kevin C. Ward, Sandy Kwong, Cyllene R. Morris, John Arend, Valerie Somma, Lou Gonsalves, Sumitha Nagarajan, Julie Ruterbusch, Ann G Schwartz, Alfreda Woods, David J Lee, Gary M Levin, Rana Bayakly, Daphne Y. Lichtensztajn, Meg McKinley, Judy R Rees, Anshu Shrestha, Brenda Y. Hernandez, Amy MM Yamamoto, Christopher J Johnson, Bożena M Morawski, Lori Koch, Ainur Aiypkhanova, Taylor Eisele, Suzanne Bentler, Mary E. Charlton, Sarma Garimella, Sue‐Min Lai, Eric B Durbin, Bin Huang, T. C. Tucker, Lihua Liu, Mei‐Chin Hsieh, Xiao-Cheng Wu, Carolyn Bancroft, Jennifer H Hayes, Benjamin Leo, Richard Knowlton, Georgetta Alverson, Tamara Weaver, Jay Desai, Mona Highsmith, Deirdre Rogers, Iris Zachary, D Lemons, H J Zimmerman, Mark Watson, Aundrea Ogushi, Wilhelmina Ross, Rani Reed, Whitney Hammond, Judith R Rees, Lisa Paddock, Antoinette M. Stroup, Angela W. Meisner, Charles Wiggins, Tabassum Z. Insaf, Baozhen Qiao, Chandrika Rao, Fatma Simsek, S. Christina Oancea, Yun Zheng, Emily Bunt, R M Slocumb, Meagan Carter, K G Aird, T Beran, Wendy Aldinger, Junhie Oh, T A Janes, Stephen M Schwartz, S Chiodini, Bezawit E. Kase, Martin Whiteside, Keisha L Musonda, Sandi L. Pruitt, Kimberly A. Herget, Morgan M. Millar, Michael R. Flaherty, Jennifer Kachajian, M B Keitheri Cheteri, Patti Migliore Santiago, Steven E. Blankenship, Jaunita L Conaway, Jessica Link Reeve, Lena C Swander, J.R. Espinoza, Joseph Grandpre, Nickhill H Bhakta, Angela Mariotto, Mary Elizabeth O'Neil, Carlos Rodriguez-Galindo, Hannah K. Weir, Reda Wilson, Elvynna Leong, SokKing Ong, Wanqing Chen, Wenqiang Wei, Anna Demetriou, Konstantine Kazanjan, Prashant Mathur, Julyanti Agustina, Desy Khairina, Lital Keinan-Boker, Barbara Silverman, Hidemi Ito, Yuriko N. Koyanagi, Masako Satô, F Tobori, Masashi Matsuzaka, Rina Tanaka, Yoshitaka Hippo, Nobuaki Michihata, Norihiro Teramoto, Natsumi Yamashita, Masakazu Hattori, Yasuharu Kaizaki, Hiroshi Kumagai, Junichi Nakashima, Fumitaka Moki, Hiromi Sugiyama, Takashi Oda, Satoru Maruyama, Nobuki Todo, Makiko Nishimura, Keiichi YOSHIDA, K Kurosawa, Y Nemoto, Hiroto Narimatsu, Kaname Watanabe, Chieko Kawamura, Yuji Koduka, Seiki Kanemura, Masayoshi Yoshida, Masaaki Kobayashi, Michiko Naito, Isao Miyashiro, Kayo Nakata, Daisuke Mori, Mayuko Yoshitake, Narue Nakabayashi, Kenji Tamura, Shin Fujita, Izumi Oki, Aya Kinjo, Yoneatsu Osaki, Norimasa Fukushima, Akiko Shibata, K Iwasa, Chie Ono, Tomohiro Matsuda, Eiman Alawadhi, A Elbasmi, Erdenekhuu Nansalmaa, Undarmaa Tudev, C. Ochir, Al Hareth M Al Khater, M.M. El Mistiri, Mushabbab A Al Asiri, Eman Alkhalawi, Mingshi Cai, Ling Li Foo, Kyu-won Jung, Eun Hye Park, Chun‐Ju Chiang, Wen-Chung Lee, Chirapong Harnprakopsuk, Puttachart Maneesai, Chalongpon Santong, Karnchana Daoprasert, Donsuk Pongnikorn, Atit Leklob, S Sangkitipaiboon, Sarayut Lucien Geater, Chanavee Toh, Güledal Boztaş, Okan Ceylan, Gülsen Aksoy, Hülya KARAKILINÇ, Rabia Çidan, Ayşe Kahraman, Tulin Gurbuz, F E Karaşahin, Duygu Özhan Turhan, Nilüfer Karagöz, Belgin Kurnali, Derya Bagci, Saime Nilgün Keloglu, Sultan Eser, Cankut Yakut, Merve Altinisik, Y Cavusoglu, A Türkköylü, N Üçüncü, Monika Hackl, Petra Ihle, Marina Borisevich, Tatyana Savich, K. Henau, Liesbet Van Eycken, Trayan Atanasov, Z. Valerianova, Pero Ivanko, Mario Šekerija, Jan Mužík, Miroslav Zvolský, Søren Friis, Simon M Kønig, Sheila K. Kristensen, Hans H. Storm, Kaire Innos, Margit Mägi, Brigitte Lacour, Claire Poulalhon, Volker Arndt, Silke Hermann, Frederik Peters, Annemarie Schultz, H. Kajueter, Andreas Stang, Bernd Holleczek, Natalie B Rath, Miklós Garami, Zsuzsanna Jakab, Deirdre E Murray, Maria Theresa Redaniel, Mary Harney, H Sundseth, Rocco Galasso, Giuseppe Sampietro, Massimo Melis, Camilla Calì, Fabio Savoia, Rosalia M Ragusa, Antonina Torrisi, Fabio Falcini, Alessandra Ravaioli, Luigino Dal Maso, Martina Taborelli, Claudia Casella, Antonella Puppo, Ilaria Cozzi, Enrica Santelli, Paola Ballotari, Erica Giacomazzi, Sonia Manasse, Marco Pompili, Federico Gervasi, Antonio G Russo, Luca Cavalieri d'Oro, M Rognoni, Rossella Abbate, Maria Francesca Vitale, Pasquala Pinna, Mario Usala, Walter Mazzucco, Francesco Vitale, Federica Manzoni, Milena M Maule, Enrica Migliore, Lucia Bisceglia, Francesco Cuccaro, Giuseppe Cascone, Eugenia Spata, Ivan Rashid, Santa Valenti Clemente, Daniela Piras, Francesca Bella, ­Rosario ­Tumino, Michael Mian, Fabio Vittadello, Giuseppa Candela, Tiziana Scuderi, Maria Gentilini, William Mantovani, Adele Caldarella, Gianfranco Manneschi, Fortunato Bianconi, Fabrizio Stracci, Marta Sbaraglia, Manuel Zorzi, Massimo Vicentini, Zane Baltane, A Maurina, Marcel Blum, Mohsen Mousavi, Giedrė Smailytė, Laura Steponavičienė, Miriam J Azzopardi, Neville Calleja, Gijs Geleijnse, Sabine Siesling, Tom B Johannesen, Siri Larønningen, Maciej Trojanowski, Paweł Macek, Tomasz Mierzwa, Agnieszka Rosinska, Kamila Kępska, Justyna Nieweglowska, Katarzyna Barna, Zofia Kolodziejczyk, Urszula Sulkowska, Danuta Owsiak, Edyta Garbowska, Malgorzata Meina, M Motnyk, Anna Patro, Anna Gos, Karolina Sikorska, Joanna A Didkowska, Urszula Wojciechowska, G. Forjaz de Lacerda, João Macedo, Pedro Berenguer, C. Camacho, Joana Oliveira, Ana Pais, Maria José Bento, Ana Catarina Rodrigues, Antonio Lourenço, Alexandra Mayer-da-Silva, Mihaela Bucurenci, Alexandra Neaga, Dmitry V Bogdanov, Mikhail Yuryevich Valkov, Alla Egorova, Andrey Orlov, L. V. Pikalova, Lilia D Zhuikova, Ekaterina Nazarova, Vesna Zadnik, Tina Žagar, Alojz Peterle, Marta De-La-Cruz, Arantza López-de-Munain, Montserrat Garrido, Consol Sabater, Ana Vizcaíno, Rufino Álamo Sanz, Pilar Gutiérrez Meléndez, R J Chillarón, Ana Isabel Marcos M Navarro, Rafael Marcos-Gragera, Jan Trallero, Daniel Redondo-Sanchez, M. Perez, María-Isabel Palacios-Castaño, Enrique Ramalle-Gómara, Núria Aragonés, David Parra, María Dolores Chirlaque López, A Sánchez Gil, Eva Ardanáz, Marcela Guevara, Pau Alfonso-Camos, Adela Cañete-Nieto, Marià Carulla, Jaume Galceran, Fernando Almela, Paul Dickman, Claudia E Kuehni, Claudia E Kuehni, Grit Sommer, Franco Cavalli, Matthias Lorez, Katharina Stähelin, John Broggio, Sarah Stevens, Charles Stiller, Damien Bennett, Deirdre Fitzpatrick, David Morrison, Greig Stanner, Dyfed W Huws, Stephanie Smits, Claudia Allemani, Michel P Coleman, Katerina Dadouli, V Di Carlo, Fabio Girardi, Margaret Grayson, Fatima Khan Baloch, M Matz, Pamela Minicozzi, Natalia Sanz, Marisa K Sophiea, Naomi Ssenyonga, Richard Stephens, Elizabeth Chalker, Mirka Smith, Amy Johnston, Tracey A. O'Brien, Hui You, Rowena Boyd, Sarah Dugdale, Julie Moore, Shoni Philpot, Stephanie Flak, Karen R Mead, Jessica Roydhouse, Bruna S. Ragaini, Sue Evans, Luc te Marvelde, Hamza Çakan, Karen Handley, Joanne Aitken, Christine Fowler, Chris Lewis · 发表于：The Lancet · 年份：2026 · DOI：10.1016/s0140-6736(26)00189-3 · 被引用次数：4 · 研究领域：Acute Lymphoblastic Leukemia research、Childhood Cancer Survivors' Quality of Life、Pharmaceutical studies and practices

BACKGROUND: CONCORD is a global public health programme for long-term surveillance of population-based cancer survival. The first three cycles of this programme focused primarily on adults. In CONCORD-4, for the first time, we also included all cancers in children. The WHO Global Initiative for Childhood Cancer (GICC), published in 2018, set a target for 5-year survival for all childhood cancers combined, worldwide, to reach 60% by 2030. We designed the protocol for CONCORD-4 to assess progress towards this target in as many countries as possible. METHODS: We identified population-based cancer registries from the members of the International Association of Cancer Registries and other sources. We invited 513 registries in 101 countries to submit anonymised individual records for all children (aged 0-14 years) living in their territory who were diagnosed with any form of cancer during the 30-year period 1990-2019, or later years. The data included demographic variables, the morphological type and anatomical location of the tumour, and the follow-up for the vital status of each child. We used the data for 2010-19 to construct a set of weights that reflect the global frequency distribution of childhood cancers, by age, sex, and subtype, both for the 12 major groups in the third edition of the International Classification of Childhood Cancer (ICCC-3) and for the six WHO tracer cancers prioritised in the GICC. We estimated 5-year net survival for children diagnosed during 1990-2019...