Trimester-specific association of gestational Atherogenic Index of Plasma (AIP) with adverse pregnancy outcomes among women with and without GDM: a cohort study

作者：Lanfang Zhao, Yuxiao Huang, Li Wang, Z W Ding, Jingjing Liu, T Y Fan, Tianli Zhu, Mengjuan Lu, Hong Gan, Hui Gao, Huayan Mo, Lanci Xie, Shuangqin Yan, Guopeng Gao, Xiayan Yu, Wenjing Qiang, Yuanjie Pang, F B Tao, Beibei Zhu · 发表于：BMC Endocrine Disorders · 年份：2026 · DOI：10.1186/s12902-026-02237-7 · 被引用次数：1 · 研究领域：Gestational Diabetes Research and Management、Pregnancy and preeclampsia studies、Cardiovascular Issues in Pregnancy

BACKGROUND: Atherogenic Index of Plasma (AIP) is a well-recognized marker for cardiovascular disease (CVD), however, its impact on adverse pregnancy outcomes (APOs) has been rarely explored, with particular uncertainty about whether the associations differ between women with and without gestational diabetes mellitus (GDM). METHODS: Pregnant women were recruited between 24 and 28 gestational weeks at Ma’anshan maternal and child health care center (Anhui Province, China) from June 2021 to December 2022. AIP values were calculated for 862 participants during both the second and the third trimester, using blood lipid data extracted from the electronic medical records. Selected APOs included preterm birth (PTB), low birth weight (LBW), and macrosomia. Logistic regression was performed to examine the association of AIP with selected APOs—both in full sample and stratified by GDM diagnosis status. Receiver operating characteristic (ROC) curves were used to illustrate the predictive ability of AIP values and individual lipid indicators for selected APOs. RESULTS: Associations of AIP with selected APOs were observed in the non-GDM group but not in the GDM group and were more pronounced in the third pregnancy: In the second-trimester, lower AIP levels were significantly associated with an increased risk of PTB (OR = 3.234; 95%CI: 1.018 to 10.275; P=0.047); In the third trimester, lower AIP was correlated with higher risks of both PTB (OR = 4.866; 95%CI: 1.583 to 14.955; P ༝0.006) and ...