Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026

作者：Hallie C. Prescott, Massimo M. Antonelli, Waleed A. Alhazzani, M. Møller, Fayez Ebrahim Alshamsi, Luciano C. P. Azevedo, Emilie P. Belley‐Côté, Jan De Waele, Lennie Derde, Joanna Colleen Dionne, L.E. Evans, Hayley Beth Gershengorn, Carol Lynette Hodgson, Kimia Honarmand, Jozef Kesecioğlu, Lauralyn McIntyre, Mervyn Mer, Mark Nunnally, Simon J. W. Oczkowski, Bram N. Rochwerg, Olurotimi Olaolu Akinola, Kwame Asante Akuamoah-Boateng, Laura Alberto, Derek C. Angus, Yassen Arabi, Elie Azoulay, Maurizio Cecconi, Pauline F. Convocar, Gennaro DE PASCALE, Kent Doi, Bin Du, Moritoki Egi, Marie-Carmelle Elie-Turenne, Ricard Ferrer, Alison Fox-Robichaud, Craig French, Yonathan Freund, Michelle Ng Gong, Caleb P. Hale, Naomi E. Hammond, Madiha Hashmi, Leo Heunks, Theodore John Iwashyna, Shevin T. Jacob, Michael Klompas, Arthur Kwizera, Murdoch Leeies, Joanna D. Lejnieks, Mitchell M. Levy, Flavia R. Machado, M. D. Maia, Henry Masur, Ryan C. Maves, Steven A. McGloughlin, Joanne McPeake, Nicholas M. Mohr, Sheila Nainan Myatra, Marlies Ostermann, Sandra L. Peake, Mathias W. Pletz, Jay Roberts, Regis G. Rosa, Robert G. Sawyer, Christa Schorr, Steven Q. Simpson, Li Weng, Willem Joost Wiersinga, Andrew Rhodes, Craig M. Coopersmith · 发表于：Critical Care Medicine · 年份：2026 · DOI：10.1097/ccm.0000000000007075 · 被引用次数：75 · 研究领域：Sepsis Diagnosis and Treatment、Nosocomial Infections in ICU、Bacterial Identification and Susceptibility Testing

Sepsis, life-threatening acute organ dysfunction due to infection (1), is a global health priority (2,3) with approximately 49 million cases and 13 million sepsis-related deaths each year (4–6). Beyond being acutely deadly, sepsis contributes to new and worsened physical, cognitive, and mental health problems in many survivors (7,8). Early identification and treatment are critical to improving outcomes. The Surviving Sepsis Campaign (SSC) guidelines are intended to support clinicians caring for adult patients with sepsis, focusing on management in the hospital, the immediate prehospital setting, and the immediate post-hospital setting. These guidelines incorporate principles of antimicrobial stewardship through responsible antimicrobial use, proper diagnostic strategies, and de-escalation of antimicrobial therapy. The recommendations reflect evidence-based best practice, distilling a large body of research into actionable recommendations. They empower individuals and health systems to make informed choices about care and support improvements in management and outcomes of sepsis (Table 1).TABLE 1.: Table of StatementsMETHODS Details on the guidelines scope, relationship to SSC bundles, history, and sponsorship; committee selection, characteristics, and organization; conflicts of interest management; patient, intervention, comparator, outcome (PICO) question selection; outcomes prioritization; evidence synthesis; certainty of evidence assessment; recommendation formulation; con...