Periodontitis Phenotypes and Treatment Outcomes Following Combined Periodontal and Orthodontic Therapy: A Cohort Study

作者：Hongtao Jiang, Qi Zhao, Zhaoxin Dong, Tianhao Li, Jiang Sun · 发表于：Clinical Cosmetic and Investigational Dentistry · 年份：2026 · DOI：10.2147/ccide.s592473 · 被引用次数：1 · 研究领域：Oral microbiology and periodontitis research、Periodontal Regeneration and Treatments、Orthodontics and Dentofacial Orthopedics

Background and Objectives: Periodontitis is a heterogeneous condition, and patients may respond differently to combined periodontal and orthodontic treatment. This study aims to identify latent phenotypes of periodontitis and to evaluate their associations with recurrence and bone regeneration after combined periodontal-orthodontic treatment. Methods: This single-centre observational cohort study included patients with periodontitis who completed combined periodontal and orthodontic treatment in 2023 and were followed for approximately two years, with re-evaluations conducted between January and July 2025. Latent class analysis was used to identify periodontitis phenotypes based on baseline periodontal characteristics. Outcomes included recurrence of periodontitis and bone regeneration. Associations between phenotypes and outcomes were examined using logistic regression models adjusted for age, sex, smoking status, and diabetes. Subgroup analyses were conducted by sex and age. Results: Four distinct periodontitis phenotypes were identified: an inflammatory type, a high inflammation and structural damage type, a moderate and stable type, and a mild or minimal damage type. Compared with the mild or minimal damage phenotype, the high inflammation and structural damage phenotype was associated with a significantly higher risk of recurrence (OR 6.67, 95% CI 2.60-18.48). For bone regeneration, both the high inflammation and structural damage phenotype, and the moderate and stable p...