Enhanced corneal retention of hyaluronic acid via a metabolic glycoengineering-based in vivo bioorthogonal reaction

作者：Buwei Hu, Hui Wang, Chenli Ji, Xuehan Xu, Luyi Wang, Tingting Cao, Menghua Gao, Yanjun Zhao, Bin Wang, Wenjing Xuan, Jianjun Cheng · 发表于：Biomaterials Science · 年份：2026 · DOI：10.1039/d5bm01898f · 被引用次数：2 · 研究领域：Proteoglycans and glycosaminoglycans research、Ocular Surface and Contact Lens、Ocular Infections and Treatments

bioorthogonal reaction that enhanced HA retention (up to 6 h) by 2.5-fold compared to the control without AAM pretreatment. The prolonged corneal retention enhanced the therapeutic efficacy at a reduced dosing frequency. This approach offers a clinically translatable strategy to improve the efficacy of topical HA-based therapies for ocular diseases.