Relationship between cerebral perfusion and cognition in white matter hyperintensities of presumed vascular origin: A prospective 3D-pCASL study

作者：F X Meng, Guangwei Jin, Ying Yang, Wen Qin, Weidong Zhou, Weiyan Mo, Sujie Chang, Meng Wang, Jun Wang, Changchun Liu, Jian Liu, Shuo Yin, Xin Chang, Gang Deng, Xin Ren, Xiaoxu Duan · 发表于：Medicine · 年份：2026 · DOI：10.1097/md.0000000000047996 · 被引用次数：1 · 研究领域：Acute Ischemic Stroke Management、Dementia and Cognitive Impairment Research、Neurological Disease Mechanisms and Treatments

White matter hyperintensities of presumed vascular origin (WMH) are known imaging markers of cerebral small vessel disease and have been associated with future stroke risk, cognitive decline, and other adverse outcomes. However, the pathogenesis of WMH and its correlation with cerebral perfusion and cognitive impairment remain unclear. In this prospective study, we included 128 participants, each of whom underwent cognitive assessments and a three-dimensional pseudo-continuous arterial spin labeling sequence, using post-labeling delay values of 1525 and 2525 ms. The magnetic resonance imaging results of all participants were categorized into 4 groups based on the Fazekas visual rating scale. Variance analyses were conducted among the 4 groups of cerebral blood flow (CBF), and partial correlation analyses were performed between CBF and cognitive function. No clusters with a CBF1525ms difference were identified among the 4 groups. Three clusters with the CBF2525ms differences were identified among the 4 groups. The CBF2525ms of the brain regions with perfusion differences among the 4 groups showed an increasing trend with increasing Fazekas grades. A negative correlation was observed between CBF2525ms in the left lenticular nucleus and the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores (r = -0.306, P < .001, and r = -0.269, P = .002). The CBF2525ms of the right lenticular nucleus was negatively correlated with the MMSE and MoCA scores (r = ...