Retrospective study of photodynamic therapy for the GNA-Related Capillary Malformation spectrum of pediatric patients

作者：Rui He, Xiaoyang Wang, Li Ma, Zhe Xu, Bin Zhang · 发表于：Photodiagnosis and Photodynamic Therapy · 年份：2026 · DOI：10.1016/j.pdpdt.2026.105448 · 被引用次数：1 · 研究领域：Vascular Malformations and Hemangiomas、Biomedical Research and Pathophysiology、Autoimmune Bullous Skin Diseases

• The GNA-Related Capillary malformation spectrum (GNARCMs) presents a therapeutic challenge. The clinical manifestations of the pediatric GNARCMs patients were retrospectively analyzed, and evaluated the efficacy and safety of photodynamic therapy for treating the GNARCMs of pediatric patients. In conclusion, focusing on the various clinical manifestations of the GNARCMs, after except contraindications, photodynamic therapy can be selected for treatment of pediatric patients, and its effectiveness and safety are worthy of affirmation. Vascular malformations caused by GNAQ/GNA11 somatic mutations are related to capillary malformations (CM), which include port-wine stains (PWS), and also include capillary malformation-related syndromes, such as Sturge-Weber syndrome (SWS), capillary malformation with overgrowth (CMO), diffuse capillary malformation with overgrowth (DCMO), and phakomatosis pigmentovascularis (PPV). These disorders are known as the GNA-Related Capillary malformation spectrum (GNARCMs). This spectrum presents a therapeutic challenge. This study aimed to evaluate the efficacy and safety of photodynamic therapy (PDT) for treating the GNARCMs of pediatric patients. The clinical manifestations of the pediatric GNARCMs patients were retrospectively analyzed, and the treatment data were assessed after undergoing PDT mediated with a combination of Hemoporfin and 532-nm light. For evaluation of improvement, photographs taken before and after photodynamic therapy were eva...