Chimeric antigen receptor T cell targeting CD44E variant in HCC holds therapeutic potential

作者：Rui Liao, Cecilia Ka Wing Chan, Yuanbin Cui, Shanglin Li, Ruiying Ma, Dongdong Peng, Piaorong Mei, Mingjing Xu, Peng Li, Nathalie Wong · 发表于：Molecular Therapy Oncology · 年份：2026 · DOI：10.1016/j.omton.2026.201181 · 研究领域：CAR-T cell therapy research、T-cell and B-cell Immunology、Monoclonal and Polyclonal Antibodies Research

models and importantly, did not induce detectable toxicity in vital organs in animal models. Our findings suggested that CD44E-targeting CAR T cell therapy might represent a promising therapeutic approach for HCC treatment.