Efficacy and safety of Telitacicept in IgA nephropathy and its impact on urinary Gd-IgA1: insights from a real-world study

作者：Hongfen Li, Wenying Li, Fanghao Wang, Yue Xing, Zhanfei Wu, Junya Jia, Youxia Liu, Tiekun Yan · 发表于：Frontiers in Immunology · 年份：2026 · DOI：10.3389/fimmu.2026.1694197 · 被引用次数：1 · 研究领域：Renal Diseases and Glomerulopathies、Monoclonal and Polyclonal Antibodies Research、Chronic Kidney Disease and Diabetes

Objective: In this study, we evaluated the efficacy and safety of Telitacicept for treating patients with primary IgA nephropathy (IgAN) in our single hospital. We also explored the effect of Telitacicept on urinary Gd-IgA1 levels among patients with IgAN. Methods: ), gender (man vs. woman), age (≥ 35 vs. < 35 years) and therapy options (Telitacicept vs. Telitacicept plus glucocorticoid/immunosuppressor) to evaluate the therapeutic effect of Telitacicept on IgAN. We conducted a propensity score-matched comparison of the primary outcome between 20 IgAN patients with Telitacicept plus supportive treatment and 20 patients with supportive care alone. The urinary Gd-IgA1 levels were determined using ELISA. Results: A total of 68 IgAN patients who received Telitacicept were included in this study. At baseline, the median baseline proteinuria was 1753.5 mg/day, and eGFR was 71.5 ml/min/1.73m². Significant reductions in proteinuria were observed at 1 month and sustained through 6 months of follow-up. The eGFR remained stable throughout the follow-up period. Subgroup analyses stratified by baseline proteinuria, eGFR, gender, age, and therapy options showed no significant differences in proteinuria reduction rates. Both patients initially starting Telitacicept and those who had previously failed other therapy before starting it showed significant reductions in proteinuria and stable eGFR. Importantly, we observed an improvement in the eGFR slope within the Prior Treatment plus Telitaci...