Intravenous thrombolysis for acute central retinal artery occlusion: Protocol for a systematic review and individual participant data meta-analysis of randomized controlled trials

作者：Brian Mac Grory, Cécile Preterre, Pierre Lebranchu, Stephen James Ryan, Øystein Kalsnes Jørstad, Morten Carstens Moe, Johannes Tünnerhoff, Martin S. Spitzer, Carsten Grohmann, Oana M. Dumitrascu, Valérie Biousse, B. Guillon, Anne Hege Aamodt, Sven Poli, Matthew Schrag, The Central Retinal ArterY OcclusioN (CRAYON) Collaborators · 发表于：PLoS ONE · 年份：2026 · DOI：10.1371/journal.pone.0342739 · 被引用次数：3 · 研究领域：Retinal and Optic Conditions、Intraoperative Neuromonitoring and Anesthetic Effects、Ocular Diseases and Behçet’s Syndrome

IMPORTANCE: Central retinal artery occlusion (CRAO) is a disabling subtype of acute ischemic stroke. It is not known whether intravenous (IV) thrombolysis delivered within 4.5 hours of time last known well (LKW) improves visual outcomes. STUDY DESIGN: Systematic review and individual participant data meta-analysis. OBJECTIVE: The objective of this study is to determine whether IV thrombolysis improves visual outcomes among patients with acute non-arteritic CRAO when administered within 4.5 hours of time LKW compared with placebo, no IV thrombolysis, and/or anti-thrombotic therapy. EVIDENCE REVIEW PLAN: This study is prospectively registered through PROSPERO (#1154900). We will include randomized controlled trials (RCTs) that enroll patients with non-arteritic CRAO presenting within 4.5 hours of time LKW. We will not include non-controlled interventional studies or retrospective studies. We will search MEDLINE, Embase, the Cochrane Library, Web of Science, and the ClinicalTrials.gov registry from inception through the date of commencement of the systematic review. We will assess the risk of bias using the Cochrane Risk of Bias Tool 2.0. We will contact the corresponding author(s) of any studies identified that meet the study selection criteria. We will inspect, harmonize, and collate trial datasets. The primary end point will be attainment of a final best corrected visual acuity (BCVA) equal to or better than 20/63 (logarithm of the minimum angle of resolution [logMAR] of ≤0.5...