Evaluation of physiological bone metabolic activity in the spine with 18F-fluorodeoxyglucose and 18F-sodium fluoride PET: associations with degenerative risk factors

作者：Shiv Patil, William Lee, Raj N. Patel, Alexander Gerlach, Darshil Patel, Rithvik Kata, Ondrej Fanta, Talha Khan, Fnu Jeevika, Cyrus Ayubcha, Jaskeerat Gujral, Om H. Gandhi, Thomas Werner, Henrik Wulff Christensen, Poul Flemming Høilund-Carlsen, Abass Alavi · 发表于：Nuclear Medicine Communications · 年份：2026 · DOI：10.1097/mnm.0000000000002134 · 被引用次数：2 · 研究领域：Medical Imaging Techniques and Applications、Bone and Joint Diseases、Bone health and osteoporosis research

OBJECTIVE: Imaging vertebral molecular activity with PET/computed tomography (CT) may enable earlier detection of degenerative diseases of the spine. This study aimed to evaluate physiological patterns of vertebral molecular activity and their association with degenerative risk factors with 18F-fluorodeoxyglucose (18F-FDG) and 18F-sodium fluoride (18F-NaF) PET/CT. METHODS: 120 subjects (mean age 48.8 ± 14.1 years, 51% male) underwent 18F-FDG and 18F-NaF PET/CT imaging. The TotalSegmentator software was used to automatically generate regions of interest surrounding each vertebral body to quantify mean standardized uptake value (SUVmean) for each radiotracer, average Hounsfield Units, and volume. RESULTS: Cervical and lumbar 18F-FDG SUVmean exceeded thoracic uptake (P < 0.01). 18F-NaF activity was greatest in the lumbar spine, followed by the thoracic and the cervical regions (P < 0.01). 18F-FDG SUVmean was associated with age (ρ = 0.19, P = 0.03, cervical), BMI (ρ = 0.28-0.40, P < 0.01, all regions), bone density (ρ = -0.30, P = 0.01, cervical), and volume (ρ = -0.20, P = 0.02, cervical). 18F-NaF SUVmean correlated with age (ρ = 0.21 and -0.20, P ≤ 0.03 in cervical and lumbar regions, respectively), BMI (ρ = 0.23 and 0.26, P ≤ 0.01in thoracic and lumbar regions, respectively), bone density (ρ = 0.38, P < 0.01, lumbar), and volume (ρ = -0.30, P < 0.01, lumbar). Cervical 18F-FDG and 18F-NaF SUVmean were higher in females than males. CONCLUSION: 18F-FDG and 18F-NaF PET/CT reveal ...