The Enhanced Effect of Q‐Switched Nd:YAG Laser (1064‐nm) Combined With Glycolic Acid on Keratosis Pilaris: A Split‐Body Randomized Clinical Trial

作者：Man Li, Xiaoduo Liu, Ruofei Yuan, Yue Bai, Zhixuan Duan, Yi Liu, Xuelei Liang, Haixuan Wu, Fenglin Zhuo · 发表于：Dermatologic Therapy · 年份：2026 · DOI：10.1155/dth/1491351 · 研究领域：Dermatologic Treatments and Research、Hair Growth and Disorders、Genetic and rare skin diseases.

Background The Q‐switched Nd:YAG laser (1064‐nm) has been reported to be the best choice for keratosis pilaris (KP) with a high frequency of treatment. Glycolic acid (GA) is known to correct abnormal keratinization and accelerate melanin metabolism. However, the combined effect of Q‐switched Nd:YAG laser (1064‐nm) and GA on KP has not been studied. Objective To evaluate the efficacy and safety of combining Q‐switched Nd:YAG laser (1064‐nm) with 30% GA in the treatment of KP. Method This prospective, rater‐blinded split‐body comparative study was conducted on patients with bilateral KP on their upper arm. Each participant’s arms were randomly assigned to either the combination group (treated with 30% GA followed by Q‐switched Nd:YAG laser) or the control group (treated with Q‐switched Nd:YAG laser alone). Treatments were administered in four sessions, 3 weeks apart. The primary endpoint was the difference in average physicians’ assessment scores between groups. The secondary endpoints were the patients’ self‐assessment scores, dermoscopic and ultrasonographic improvements, and adverse effects. Clinical, dermoscopic, and ultrasonographic assessments were conducted at baseline and 4 weeks after the final treatment. Result A total of 22 patients completed the study. Physicians’ assessment indicated significant improvements in both roughness and redness scores from baseline to final follow‐up in both groups (all p < 0.01). In between‐group comparisons, both physician and patien...