Novel insights into autoimmune gastritis: clinical profile and gastric neoplastic risk from an international multicentre study

作者：Marco Vincenzo Lenti, Emanuela Miceli, İrfan Soykan, Arnoldo P. Riquelme, Gonzalo Latorre, Marcia Roxana Cruz-Correa, Olga Leanette Diaz-miranda, Hilmaris Centeno‐Girona, Ingrid M. Montes‐Rodríguez, María González-Pons, Ken Haruma, Peter Malfertheiner, Marino Venerito, Julian-Yannick Baur, Monika Laszkowska, Vivian E. Mack Strong, Tamara Matysiak‐Budnik, Amaury Druet, Nicolas Chapelle, Jerome Martin, Shailja C Shah, M ̄arcis Leja, Sara Massironi, Edith Lahner, Bruno Annibale, Alessandra Bonfichi, Gabriele Natalello, Carmine Frenna, Clarissa Petrucci, Andrea Quadrelli, Mariangela Delliponti, Marco Paulli, Alessandro Vanoli, Shamim Joudaki, Francisca Venezian, Juan Carlos Roa, Sara Maquilón, Alberto Espino, Jose Ignacio Vargas, Elena Maria De Giorgi, Valeria Musella, Gino Roberto Corazza, Catherine Klersy, M. Constanza Camargo, Antonio Di Sabatino · 发表于：Gut · 年份：2026 · 被引用次数：14 · 研究领域：Helicobacter pylori-related gastroenterology studies、Liver Diseases and Immunity、Microscopic Colitis

Background International comparative data on autoimmune gastritis (AIG) remain limited. Objective We aimed to describe AIG features and quantify the risk of gastric adenocarcinoma and type 1 gastric neuroendocrine tumours (NETs). Design Retrospective study across eight tertiary centres in Europe, Türkiye, Latin America, the USA and Japan. Adults with histologically confirmed AIG were included. Clinical and follow-up data were collected to estimate adenocarcinoma and NET incidence and associated factors. Results 1240 patients were included (female:male 2:1; median age 59, IQR 48–67; median follow-up 68 months, IQR 36–108). Macrocytic anaemia predominated in Europe (45.6%), microcytic anaemia in Türkiye (56.1%) and Latin America (64.7%). Autoimmune comorbidities were most frequent in Latin America (67.7%). 36 (2.9%) gastric adenocarcinomas and 132 (10.6%) NETs occurred. No incident adenocarcinomas were reported in Latin America or Japan cohorts. Crude incidence rates ranged from 1.15 to 1.47 for adenocarcinoma and 0.70 to 1.62/100 person-years for NETs. Factors associated with adenocarcinoma included age >65 years (OR 4.50, 95% CI 2.18 to 9.27), intestinal metaplasia (OR 1.51, 95% CI 1.16 to 1.97), gastrin-17 >1316 pg/mL (OR 15.52, 95% CI 3.61 to 66.71) and prior proton pump inhibitor (PPI) (OR 5.74, 95% CI 2.13 to 15.47). For NETs, prior PPI (OR 2.69, 95% CI 1.12 to 6.46), smoking (OR 2.45, 95% CI 1.75 to 3.42), intestinal metaplasia (OR 2.88, 95% CI 1.38 to 6.01) and gastrin-...