Association between perivascular diffusion and white matter microstructural integrity, free water, Aβ burden, and cognition: diffusion tensor vs. kurtosis tensor

作者：Zhiming Zeng, Xin Jia, Shushu Han, Cuidie Zeng, J. Bi, Lingchen Liu, Yue Wu, Gao Tl, Lei Liang, Fangxiao Cheng · 发表于：Frontiers in Aging Neuroscience · 年份：2026 · DOI：10.3389/fnagi.2026.1733820 · 被引用次数：3 · 研究领域：Cerebrospinal fluid and hydrocephalus、Advanced Neuroimaging Techniques and Applications、Spinal Dysraphism and Malformations

Background Perivascular diffusion holds great potential for the non-invasive assessment of the glymphatic system (GS). However, Gaussian model-based diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) is limited by microstructural alterations. This study aimed to compare cross-sectional and longitudinal trajectories of diffusion kurtosis imaging ALPS (DKI-ALPS) and DTI-ALPS and investigate their association with white matter (WM) microstructural integrity, free water (FW), Aβ burden, and cognitive impairment (CI). Methods This study included 128 healthy controls (HCs) and 83 individuals with cognitive impairment (CI) who underwent multi-shell diffusion-weighted magnetic resonance imaging (dMRI). Four dMRI indices were quantified: DTI-ALPS and DKI-ALPS to assess the GS function; peak width of skeletonized mean diffusivity (PSMD) to evaluate the WM microstructural integrity; and FW-WM to quantify the extracellular fluid accumulation in WM. Cohen’s d was reported as the measure of effect size, with generalized linear models (GLMs) adjusting for confounding factors. Functional principal component analysis (FPCA) was used to determine the trajectories of dMRI indices. Results CIs exhibited significantly lower DTI-ALPS (1.28 vs. 1.37; p = 0.007; Cohen’s d = 0.383) and DKI-ALPS (1.37 vs. 1.63, p < 0.001; Cohen’s d = 0.770) than HCs. GLMs confirmed significant group differences in DKI-ALPS indices. DTI-ALPS was positively correlated with DKI-ALPS ( r = 0.551; p ...