Targeting VEGFR2 inhibition within a spatially-confined conduit promotes nerve self-resolution and alleviates mechanical allodynia

作者：Xiaobin Luo, Toshitatsu Nagayasu, Yuhao Zhang, Zhi He, Jia Yang, Chengli Li, Guman Duan, Qunchuan Zong, Yun Liu, Kaiyuan Yang, Kaige Mao, Pengchao Ma, Zifan Li, Yating Zhao, Kunkoo Kim, Jie Zhang, Zide Wang, Yuyang Luo, Jingsong Lu, Sengpav Tong, Jia-kuo Yu, Zhe Zhao, Zheng Cao, Shuhui Yang, Yongwei Pan, Xiumei Wang · 发表于：Bioactive Materials · 年份：2026 · DOI：10.1016/j.bioactmat.2026.03.009 · 研究领域：Angiogenesis and VEGF in Cancer、Axon Guidance and Neuronal Signaling、Cellular Mechanics and Interactions

MPs distributed in the peripheral nerve stumps indirectly downregulated pain-related proteins (TRPA1/CGRP) in dorsal root ganglia and suppressed spinal microglial activation. Overall, this study presents a comprehensive and safe vascular-targeted strategy promoting nerve end interface self-resolution and prevention of neuropathic pain.