J-Editing Proton MR Spectroscopy for Brain Signal Separation in Methylmalonic Acidemia: A Pediatric Case-Control Study

作者：Mengyuan Zhuo, Yan Yun, Jiaxiang Xin, Aocai Yang, Yufan Chen, Y L Zhao, Guangbin Wang · 发表于：Radiology · 年份：2026 · DOI：10.1148/radiol.251117 · 被引用次数：1 · 研究领域：Metabolism and Genetic Disorders、Folate and B Vitamins Research、Advanced MRI Techniques and Applications

J-editing proton MR spectroscopy enabled in vivo separation of cerebral methylmalonic acid (MMA) and lactate signals in methylmalonic acidemia, and the MMA signal intensity correlated with blood propionylcarnitine to acetylcarnitine ratio and urinary MMA levels.