Comprehensively investigating pharmacokinetics and metabolic fate of andrographolide in rats by liquid chromatography/mass spectrometry-based approach

作者：Xuelin Sun, Yatong Zhang, Zhanpeng Shang, Lin Dou, T Y Wang, Jiantao Qiu, Shuang Chen · 发表于：RSC Advances · 年份：2026 · DOI：10.1039/d5ra08654j · 被引用次数：2 · 研究领域：Andrographolide Research and Applications、Traditional Chinese Medicine Analysis、Magnolia and Illicium research

In vivo disposition of Andrographolide was studied in rats. It showed high elimination and moderate bioavailability. 34/39 metabolites were sulfated, making sulfation its main pathway. A novel MS/MS workflow identified 4 sulfation sites.