Underrated, Unvaccinated, Untreated: A Multinational Registry Analysis of Human Metapneumovirus in Hematological Malignancy, Insights From EPICOVIDEHA/EPIRESEHA Registry

作者：Jon Salmanton-García, F. Marchesi, Erica Mackenzie, Inmaculada Heras-Fernando, Iker Falces-Romero, Antonio Roig Vena, Carolina Garcia-Vidal, Barbora Weinbergerová, Nicola Sgherza, Klára Piukovics, Gustavo Adolfo Méndez, Dario Leotta, Alberto López-García, Francesca Farina, Nurettin Erben, Yavuz M. Bilgin, Monika Biernat, Verena Petzer, Gabriele Magliano, Ľuboš Drgoňa, Benjamín Víšek, Andrés Soto-Silva, Michail Samarkos, Milan Navrátil, Tobias Lahmer, N. Stefano Fracchiolla, Donald C Vinh, L. Prezioso, Nikola Pantić, S. N. Khostelidi, Reham Abdelaziz Khedr, Noha Eisa, Michelina Dargenio, Caterina Buquicchio, László Imre Pinczés, Mario Virgilio Papa, Patricia García Ramírez, Anna Dąbrowska-Iwanicka, Annarosa Cuccaro, Nataša Čolović, Martin Čerňan, Jens Van Praet, Toni Valković, Gaëtan Plantefeve, Maria Merelli, J. Labrador, Martin Kolditz, Andreas Glenthøj, Ildefonso Espigado, Simge Erdem, J. Drozd-Sokołowska, Mario Delia, Claudio Cerchione, Chiara Cattaneo, Josip Batinić, Alejandro Avendaño, Ahlam Almasari, Romane Prin, Davide Nappi, Pellegrino Musto, Ditte Stampe Hersby, Elena Arellano, Marta Callejas-Charavía, Gina Varricchio, Mirjana Mitrović, Amalia Anastasopoulou, Dominik Wolf, Raúl Córdoba, A Romano, Tommaso Francesco Aiello, Martina Bavastro, Alessandro Limongelli, Antonio Giordano, Sara Caterina Brunetti, Kevin Nguyen, Lukas Van Der Ven, Livio Pagano, Oliver A Cornely · 发表于：Open Forum Infectious Diseases · 年份：2026 · DOI：10.1093/ofid/ofag099 · 被引用次数：1 · 研究领域：Respiratory viral infections research、COVID-19 Clinical Research Studies、Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Abstract Background Human metapneumovirus (hMPV) is an increasingly recognized respiratory pathogen in immunocompromised patients, but its impact in haematological malignancies is poorly defined. Unlike influenza or SARS-CoV-2, hMPV has no specific treatment or vaccine, contributing to underdiagnosis and underestimation of its clinical relevance. Method We performed a multicentre retrospective cohort study within the Epidemiology of COVID-19 in patients with hematological malignancies: A European Haematology Association Survey/ Epidemiology of respiratory viral infections in patients with hematological malignancies: A European Haematology Association Survey registry of haematological patients with hMPV (January 2023–December 2024), comparing clinical features and outcomes with matched influenza and SARS-CoV-2 cohorts. Results The study included 130 patients with hMPV. Median age was 58.5 years; 57% were male. Plasma cell neoplasms (25%), lymphoma (23%), and acute myeloid leukemia (20%) were the most common hematological malignancies. Hospitalization occurred in 64%, intensive care unit (ICU) admission in 19%, and 30-day mortality was 8%. Most cases (73%) received supportive care only. Secondary infections were common (24%). Chronic renal disease significantly increased mortality risk (hazard ratio 20.9 11.05, P = .014). Compared with influenza and SARS-CoV-2, hMPV patients had comparable severity and outcomes, with 18.5% ICU admission rates versus 25.9% for influenza (P = .31...