The prognostic impact of systemic inflammation and nutritional indicators on targeted therapy for renal cell carcinoma: a systematic review and meta-analysis

作者：Yushuang Xiao, Yang Dai, Xushu Zhong, Luocheng Zhang, Ruilian Xie, Qiaolin Zhou, Wenyi Liang, Xu Sun, Mengting Yang, Zhuohang Zou, Yutong Wang, He Li, Ting Niu · 发表于：Frontiers in Nutrition · 年份：2026 · DOI：10.3389/fnut.2026.1777753 · 被引用次数：3 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Renal cell carcinoma treatment、Ferroptosis and cancer prognosis

Introduction: The prognosis of metastatic renal cell carcinoma (mRCC) varies significantly, and early treatment failure is common. Systemic inflammation and nutritional indicators may predict the survival outcomes of patients with renal cell carcinoma (RCC) receiving targeted therapy. However, an integrated evaluation of the prognostic value of these markers is still lacking. This study aims to comprehensively assess and compare the prognostic significance of various systemic inflammation and nutritional indicators for the overall survival (OS) and progression-free survival (PFS) of patients with RCC undergoing targeted therapy through systematic review and meta-analysis. Methods: According to PRISMA guidelines, a systematic search was performed across PubMed, Embase, Cochrane Library, Web of Science, Scopus, Medline up to October 17, 2025. Retrospective cohort studies evaluating the correlation between baseline inflammatory/nutritional indicators and OS/PFS in RCC patients receiving targeted therapy were included. And biomarkers included Neutrophil-to-Lymphocyte Ratio (NLR), C-Reactive Protein (CRP), Platelet-to-Lymphocyte Ratio (PLR), Body Mass Index (BMI), Albumin (Alb), Prognostic Nutritional Index (PNI), Systemic Immune-Inflammation Index (SII), Neutrophil Count (NEU), and hemoglobin (Hb). Two researchers independently performed literature screening, data extraction, and quality assessment. Meta-analysis was performed using Stata 18.0. The pooled hazard ratio (HR) and it...