Investigation into the significance of CCTA-FFR, TyG index, and NLR in assessing the stenosis degree of coronary atherosclerosis

作者：Dabin Pan, Jianyuan Pan, Lintao Zha, Yang Ling, Sisi Hu, Quan Zuo · 发表于：Journal of Investigative Medicine · 年份：2026 · DOI：10.1177/10815589261429533 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Cardiovascular Disease and Adiposity、Cerebrovascular and Carotid Artery Diseases

This study aimed to investigate the predictive significance of fractional flow reserve derived from coronary computed tomography angiography (CCTA-FFR), lipid profiles, the triglyceride glucose (TyG) index, and the neutrophil-to-lymphocyte ratio (NLR) in assessing the degree of coronary atherosclerosis stenosis. This retrospective study analyzed data from 80 patients with coronary heart disease (CHD; aged ≥55 years) who underwent CCTA. Participants were stratified into two groups using the Gensini scoring system: mild stenosis (MS) and moderate-to-severe stenosis (M-SS). Comprehensive comparisons were performed on baseline characteristics, CCTA-derived parameters (including CT-FFR and coronary artery calcium (CAC) scores), metabolic markers (fasting lipid profiles, TyG index), and systemic inflammatory indicators (platelet-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and NLR). The M-SS group exhibited significantly elevated Gensini scores (28.65 ± 2.32 vs 21.34 ± 3.48, p < 0.001), CAC scores (25.14 ± 4.86 vs 22.73 ± 3.66, p < 0.01), the TyG index (9.49 ± 1.38 vs 8.61 ± 1.11, p < 0.001), and NLR (3.12 ± 0.96 vs 2.69 ± 0.73, p < 0.02) compared with the MS group. In contrast, the CCTA-FFR value of MS group was significantly higher than of M-SS group. Notable inverse correlations were identified between CCTA-FFR and both Gensini scores and CAC scores. Moreover, NLR and the TyG index displayed positive correlations with Gensini scores and CAC scores. The integrat...