Applying FRAME-IS to characterize provider-led adaptations to a cervical cancer prevention intervention in Kenya

作者：Harriet Fridah Adhiambo, Katherine K. Thomas, Megan Coe, Lynda Oluoch, Valary Ihaji, Mary Bernadette Kerubo, Alex Kinyua, Sarah Njoroge, Kenneth Ngure, Michelle Shin, Thomas A. Odeny, Bryan Weiner, N Mugo, Sarah I. Gimbel · 发表于：Implementation Science Communications · 年份：2026 · DOI：10.1186/s43058-026-00883-5 · 研究领域：Global Maternal and Child Health、Health Policy Implementation Science、Diabetes Management and Education

BACKGROUND: Implementation strategies that are contextually refined are essential for optimizing the delivery of evidence-based interventions (EBI) to prevent cervical cancer in low-resource settings. This paper reports the application of the Framework for Reporting Adaptations and Modifications to Evidence-based Implementation Strategies (FRAME-IS) to capture and disseminate strategy adaptations made to a single-visit, screen-and-treat approach with thermal ablation (SV-SAT + TA) strategy aimed at establishing sustainable cervical cancer prevention services in Kenya. METHODS: A FRAME-IS-based tracking spreadsheet was developed to document bundled site-specific implementation strategy adaptations and across 10 facilities. Data was collected during technical assistants' (TAs) site visits, phone calls, and monthly meetings with health providers between March 2023 and September 2024. Sources of adaptation included tracking spreadsheets, TAs narrative reports, and field notes from direct observations during the implementation phase. Descriptive statistics summarized site characteristics and adaptation trends. The exact Poisson test compared adaptation rates by facility level (medium vs large) and period (early vs late). RESULTS: A total of 28 adaptations were identified. Most adaptations (70%, n = 20) occurred in the early phase. Over half were planned (57%, n = 16). We made modifications to module two (What was modified). Educational adaptations were most common (57%, n = 16), p...