A MOF-Lanthanide Theranostic Agent with Bidirectional Near-Infrared Photon Conversion for Tumor-Responsive Therapy and Real-Time Imaging

作者：Jiarui Du, Tao Jia, Dan Li, Hans Ågren, Liangcan He, Chen Guanying · 发表于：Journal of the American Chemical Society · 年份：2026 · DOI：10.1021/jacs.5c21676 · 被引用次数：2 · 研究领域：Nanoplatforms for cancer theranostics、Nanoparticle-Based Drug Delivery、Cancer, Hypoxia, and Metabolism

Smart tumor-responsive theranostic agents are crucial for advancing precision medicine by enabling targeted drug delivery with minimal off-target effects and allowing real-time monitoring of therapeutic outcomes. Although metal–organic frameworks (MOFs) hold promises as nanocarriers, they often lack integrated, stimuli-responsive imaging and therapeutic capabilities. Here, we present a multifunctional MOF-lanthanide theranostic agent featuring bidirectional near-infrared (NIR) photon conversion for image-guided, tumor-specific therapy. The MOF carrier MIL-53(Fe) encapsulates curcumin, a natural photosensitizer and chemotherapeutic agent, which is selectively released in the acidic tumor microenvironment via pH-triggered framework degradation. This degradation also releases Fe 3+ ions, initiating Fenton reactions to produce hydroxyl radicals for chemodynamic therapy (CDT). Lanthanide nanoparticles, satellited on the MOF, enable NIR-to-visible/ultraviolet upconversion to activate curcumin for photodynamic therapy (PDT), as well as NIR-to-NIR II (∼1530 nm) downshifting emission for deep-tissue imaging in vivo . Notably, the NIR II luminescence, initially quenched by metallic node ions (Fe 3+ ) in MOF, is restored during MOF degradation, allowing semi-quantitative visualization of drug release. In vivo NIR-II imaging demonstrates peak tumor accumulation of the agent at 24 h postinjection and near-complete systemic clearance by day 14. This platform achieves a synergistic chemothe...