Development of a nucleotide prodrug of 4′-fluorouridine to improve tolerability

作者：Austin T. Ryan, Jean-Marc I.A. Lawrence, Brett Virgin-Downey, Damien L. Kuiper, Michael Hager, Takashi Tomioka, Raphael S. Kim, Ami H. Asakawa, Mariah C. Meehan, Phong Truong, Shuli Mao, Manohar T. Saindaine, Zachary M. Sticher, Jose R. Marengo, Meghan K. Andrews, Rebecca E. Krueger, Amalia Cruz, McKenzie L. Smith, Rui Jin, Deborah G. Mitchell, Alexander A. Kolykhalov, Jeong-Joong Yoon, Carolin M. Lieber, Richard K. Plemper, George R. Painter, Michael G. Natchus · 发表于：European Journal of Medicinal Chemistry · 年份：2026 · DOI：10.1016/j.ejmech.2026.118692 · 研究领域：Fluorine in Organic Chemistry、DNA and Nucleic Acid Chemistry、HIV/AIDS drug development and treatment