Endothelial UNC5B regulates blood‑retinal barrier homeostasis

作者：Yongfang Yao, Suyu Wang, Jiajun Li, Qianzi Jin, Z.-Q. Chen, Qin Jiang, Keran Li · 发表于：International Journal of Molecular Medicine · 年份：2026 · DOI：10.3892/ijmm.2026.5771 · 被引用次数：1 · 研究领域：Axon Guidance and Neuronal Signaling、Angiogenesis and VEGF in Cancer、Barrier Structure and Function Studies

retinal imaging. Mechanistically, transcriptomic and protein analyses revealed that UNC5B downregulation was associated with increased extracellular matrix protein deposition and reduced Hippo pathway activity. Collectively, these findings established UNC5B as a key mediator of BRB and NVU stability, and highlighted its therapeutic potential in maintaining vascular integrity and protecting neural elements in retinal vascular diseases.