Influenza A(H3N2) subclade K (J.2.4.1) viruses associated with a surge at a university health clinic, Arizona, the United States, November to early December 2025

作者：Matthew Scotch, Temitope O. C. Faleye, Angelica Urquidez-Negrete, Bradley Bobbett, Veronica Boyle, Kelly Conard, Lucy Sublasky-Rodriguez, Vel Murugan · 发表于：Eurosurveillance · 年份：2026 · DOI：10.2807/1560-7917.es.2026.31.7.2600111 · 被引用次数：3 · 研究领域：Influenza Virus Research Studies、Respiratory viral infections research、SARS-CoV-2 and COVID-19 Research

Genomic surveillance during an influenza surge between November and early December 2025 at a university health clinic in the United States identified A(H3N2) subclade K (J.2.4.1) viruses with shared haemagglutinin amino acid substitutions in antigenic sites and the receptor-binding domain. An epitope-based model indicated reduced vaccine protection (mean predicted protection 0.13). Phylodynamic analyses suggested multiple introductions with onward campus-to-community spread, highlighting that universities and other semi-closed settings can amplify transmission and aid early characterisation of emerging lineages.