Life event trajectories and suicidal ideation throughout adolescence: a prospective cohort study from Germany, France, Ireland, and the UK

作者：Pei-Jung Chen, Andrew John Lawrence, Xuemei Ma, Rebecca Pollard, Maryam Matter, Svenja Kretzer, Seeromanie Harding, Carmine Maria Pariante, Mitul A Mehta, Giovanni Montana, Tobias Banaschewski, Arun L W Bokde, Sylvane Desrivières, Antoine Grigis, Hugh P. Garavan, Penny Gowland, Andreas Heinz, Jean-Luc Martinot, Marie-Laure Paillère Martinot, E. Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomas Paus, Luise Poustka, Sarah Hohmann, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Paul Wirsching, Gunter Schumann, Chiara Nosarti, Paola Dazzan · 发表于：The Lancet Psychiatry · 年份：2026 · DOI：10.1016/s2215-0366(25)00359-1 · 被引用次数：3 · 研究领域：Suicide and Self-Harm Studies、Health disparities and outcomes、Health, Environment, Cognitive Aging

Background Adolescence is a sensitive period when suicidal ideation can peak. Although traumatic life events are a well established risk factor for suicidal ideation, the role of cumulative ordinary life events across multiple dimensions, such as family, autonomy, and sexuality, remains underexplored. Crucially, no evidence is available on how multidimensional trajectories of cumulative exposure to such events relate to suicidal ideation throughout adolescence. We aimed to examine how cumulative and domain-specific trajectories of ordinary life events during adolescence relate to suicidal ideation. Methods In this multinational, prospective cohort study, we used longitudinal data from the IMAGEN cohort, gathered from eight centres in Germany, France, Ireland, and the UK between January, 2008, and January, 2010, to model trajectories of exposure to life events during adolescence, and to quantify the association between trajectory group and suicidal ideation. Participants were assessed at ages 14, 16, 19, and 23 years, and key inclusion criteria included having the capacity to provide informed assent or consent, and having parental completion of perinatal and developmental history. Exposure to 39 life events across seven dimensions (family, accidents, distress, autonomy, deviance, sexuality, and relocation) were assessed using the Life Events Questionnaire (LEQ), administered at each of the study timepoints. Childhood maltreatment was also assessed, using the Childhood Trauma Q...