Exercise attenuates polycystic ovary syndrome development via improved mitochondrial proteostasis

作者：Chaeyoung Shin, Liwei Chen, Md Nazmul Hossain, Xinrui Li, Sharmeen Islam, Zhongyun Kou, Qiaorong Cui, J Arnzen de Avila, Zhu Mj, ‬Min Du · 发表于：American Journal of Physiology-Endocrinology and Metabolism · 年份：2026 · DOI：10.1152/ajpendo.00457.2025 · 被引用次数：2 · 研究领域：Ovarian function and disorders、Reproductive Biology and Fertility、Ovarian cancer diagnosis and treatment

This study identifies mitochondrial proteostasis as an important molecular mechanism underlying the beneficial effects of aerobic exercise in improving polycystic ovary syndrome (PCOS). Exercise attenuated PCOS development and pathology through normalizing steroidogenic enzyme degradation via LONP1 upregulation, suppressing ovarian inflammation and fibrosis, and activating mitochondrial biogenesis pathways. Although the beneficial effects of exercise on PCOS have been well recognized, this study reveals the mitochondrial proteostasis pathway underlying these preventive effects.