Unraveling the HiddenBalance between Quantum Confinementand Structural Modifications in Near-Infrared Fluorescent Carbon Dots

作者：Muhammad Madni, Zia Ullah, Hanfang Jiang, Jhilik Roy, Yibin Yan, Dongxiang Chen, Zhengyang Jin, Xiaowei Wu, Yuante Lan, Shaohua Wang, Shubham Roy, Bing Guo · 发表于：Chemical & Biomedical Imaging · 年份：2026 · DOI：10.1021/cbmi.5c00234 · 被引用次数：7 · 研究领域：Carbon and Quantum Dots Applications、Melamine detection and toxicity、Silicon Nanostructures and Photoluminescence

Abstract Near-infrared (NIR) fluorescent carbon dots (CDs) have emerged as promising nanomaterials for advanced bioimaging, sensing, and theranostic applications due to their intrinsic biocompatibility, photostability, tunable emission, and structural versatility. However, achieving strong, stable, and predictable NIR emission remains a major challenge due to the complex interplay between quantum confinement, surface states, and structural modifications. From a synthesis standpoint, leveraging well-defined molecular precursors, precisely controlled heteroatom doping, and defect engineering provides a systematic approach to modulate emissive centers and achieve reproducible, high-performance NIR fluorescence. This review unravels the hidden balance between these governing factors and provides a unified mechanistic perspective on how sp2/sp3 domain engineering, heteroatom doping, defect modulation, and donor–acceptor interactions collectively dictate long-wavelength emission. The synthetic routes ranging from top-down to bottom-up approaches have been discussed comprehensively to highlight how precursor chemistry, reaction environment, and postsynthetic processing influence the electronic structure and photophysical behavior of CDs. Despite significant progress in optimizing the functionality of CDs, key barriers, including inconsistent synthesis, unresolved emission mechanisms, and limited translational readiness, continue to hinder clinical deployment. By bridging fundamental...